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Related Experiment Videos

Posterior corneal vesicles

G J Pardos, J H Krachmer, M J Mannis

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |September 1, 1981
    PubMed
    Summary

    This study describes unique posterior corneal vesicles and scalloped lesions in six young patients. The findings suggest these lesions are not herpetic in origin, differing from previous assumptions.

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    Area of Science:

    • Ophthalmology
    • Corneal Diseases
    • Genetics

    Background:

    • Posterior corneal vesicles and scalloped lesions are rare ocular findings.
    • Previous hypotheses suggested a herpetic etiology for these corneal abnormalities.

    Observation:

    • Six patients (2 male, 4 female), aged 7-24 years, presented with unilateral posterior corneal vesicles and scalloped lesions.
    • Lesions were located at Descemet's membrane and endothelium, with some vesicles exhibiting gray halos.
    • Specular microscopy suggested coalescence of vesicular defects as the cause of scalloped lesions.

    Findings:

    • All patients had normal visual acuities (6/6 or better) and no other ocular abnormalities.
    • Thirty unaffected family members were identified, suggesting a non-hereditary or sporadic occurrence.
    • The study's findings do not support a herpetic origin for these specific corneal lesions.

    Implications:

    • Accurate differentiation of these lesions from posterior polymorphous dystrophy, congenital glaucoma, and forceps injury is crucial.
    • Further research is needed to determine the definitive etiology of these posterior corneal abnormalities.
    • This study contributes to understanding the differential diagnosis of posterior corneal pathologies.

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