Related Experiment Videos
[Kallikrein-kinin system of the blood plasma in patients with infectious-allergic myocarditis]
Insights
This study reveals significant changes in the blood plasma kallikrein-kinin system in infectious-allergic myocarditis patients. Monitoring this system offers a new diagnostic approach for myocarditis, aiding treatment strategies.
Area of Science:
- Cardiology
- Immunology
- Biochemistry
Background:
- Infectious-allergic myocarditis poses diagnostic challenges with current clinico-laboratory criteria.
- The role of the plasma kallikrein-kinin system in this condition remains largely unexplored.
Purpose of the Study:
- To investigate the plasma kallikrein-kinin system's state in infectious-allergic myocarditis.
- To evaluate the diagnostic utility of kinin system components.
- To explore therapeutic implications for myocarditis management.
Main Methods:
- Utilized biological assays to quantify kallikrein, kininogen, kininases, and free kinins.
- Analyzed plasma samples from 38 individuals with infectious-allergic myocarditis.
Main Results:
- Detected alterations in the kinin system activity in 92% of patients.
- Observed initial activation within 2-4 months, followed by exhaustion at 6-8 months.
- Highlighted limitations of conventional diagnostic markers for myocarditis.
Conclusions:
- Plasma kallikrein-kinin system assessment is a valuable additional diagnostic marker for infectious-allergic myocarditis.
- Kinin system modulation, using antagonists and inhibitors, is a promising therapeutic strategy.
- Further research into kinin system dynamics in myocarditis is warranted.
Abstract:
The state of the blood plasma kallikrein-kinin system in infectious-allergic myocarditis was studied for the first time. Biological methods for the determination of kallikrein, kininogen, kininases, and free kinins were used. Changes in the activity of the kinin system were revealed in 92% of 38 individuals examined: activation in the first 2-4 months and exhaustion later (in 6-8 months). It was shown that the generally accepted clinico-laboratory criteria on myocarditis are not always informative. Determination of the components of the plasma kinin system is suggested as an additional diagnostic test. The use of kinin antagonists and inhibitors of the kinin system in the complex of drug therapy in infectious-allergic myocarditis is recommended.