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Pancreatic exocrine function in systemic sclerosis

I Cobden, A T Axon, N R Rowell

    The British Journal of Dermatology
    |August 1, 1981
    PubMed
    Summary
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    Pancreatic exocrine function tests in systemic sclerosis revealed significant insufficiency in many patients. However, intestinal bacterial overgrowth is a more frequent cause of malabsorption than pancreatic damage in this condition.

    Area of Science:

    • Gastroenterology
    • Immunology

    Background:

    • Systemic sclerosis is an autoimmune disease affecting connective tissues.
    • Malabsorption is a common complication in systemic sclerosis patients.

    Purpose of the Study:

    • To evaluate pancreatic exocrine function in patients with systemic sclerosis.
    • To determine the contribution of pancreatic insufficiency to malabsorption in systemic sclerosis.

    Main Methods:

    • Lundh tests were conducted on twenty unselected patients with systemic sclerosis.
    • Assessed tryptic activity in intestinal juice.
    • Investigated causes of biochemical steatorrhoea, including bacterial overgrowth and primary biliary cirrhosis.

    Main Results:

    • Only nine out of twenty patients exhibited unequivocally normal pancreatic exocrine function.

    Related Experiment Videos

  • Three patients had very low tryptic activity.
  • Eight patients had biochemical steatorrhoea; six were linked to bacterial overgrowth, one to primary biliary cirrhosis.

    • Conclusions:

    • Pancreatic damage can contribute to malabsorption in systemic sclerosis.
    • Intestinal bacterial overgrowth appears to be a more significant factor in malabsorption than pancreatic insufficiency in systemic sclerosis.