Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Establishment of normal synaptic density in deafferented olfactory cortex

B Friedman, J L Price

    Brain Research
    |October 26, 1981
    PubMed
    Summary

    Neonatal olfactory bulb removal in rats causes the piriform cortex molecular layer to develop normally. Intracortical axons replace removed olfactory bulb axons, maintaining synaptic density in the piriform cortex.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Measured optical losses of Sc doped AlN waveguides.

    Optics express·2024
    Same author

    Effects of ambient exposure, refrigeration, and icing on Vibrio vulnificus and Vibrio parahaemolyticus abundances in oysters.

    International journal of food microbiology·2017
    Same author

    Airborne Emissions of Mercury from Municipal Landfill Operations: A Short-Term Measurement Study in Florida.

    Journal of the Air & Waste Management Association (1995)·2017
    Same author

    Pros and cons of circumcision: an evidence-based overview.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016
    Same author

    Effects of Intertidal Harvest Practices on Levels of Vibrio parahaemolyticus and Vibrio vulnificus Bacteria in Oysters.

    Applied and environmental microbiology·2016
    Same author

    Communication gaps associated with donor-derived infections.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014

    Area of Science:

    • Neuroscience
    • Neuroanatomy
    • Sensory system research

    Background:

    • The piriform cortex is crucial for olfactory processing.
    • Neonatal deafferentation studies investigate neural plasticity.
    • Olfactory bulb removal disrupts normal sensory input.

    Purpose of the Study:

    • To examine the structural and synaptic plasticity of the piriform cortex after neonatal olfactory bulb removal.
    • To understand axonal replacement and synaptic organization in a deafferented sensory cortex.

    Main Methods:

    • Neonatal rats underwent olfactory bulb removal (deafferentation).
    • Piriform cortex structure and synaptic density were analyzed in adulthood.
    • Axonal tracing and electron microscopy were employed.

    Main Results:

    • The molecular layer of the piriform cortex achieved near-adult thickness despite deafferentation.
    • Removed olfactory bulb axons were extensively replaced by intracortical axons.
    • Synaptic density in the molecular layer remained comparable to normal cortex.

    Conclusions:

    • The piriform cortex exhibits significant axonal plasticity and compensatory mechanisms following early-life deafferentation.
    • Intracortical projections can functionally replace lost afferent input, preserving synaptic organization.
    • This highlights the brain's capacity for structural adaptation in response to sensory deprivation.

    Related Experiment Videos