Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central and peripheral contributions to hypothalamic epinephrine

I N Mefford, K A Roth, G Paxinos

    Brain Research
    |November 9, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABA<sub>A</sub> receptors.

    Translational psychiatry·2019
    Same author

    Quantitative validation of immunofluorescence and lectin staining using reduced CLARITY acrylamide formulations.

    Brain structure & function·2017
    Same author

    Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder.

    Translational psychiatry·2016
    Same author

    Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder.

    Translational psychiatry·2015
    Same author

    Termination of vestibulospinal fibers arising from the spinal vestibular nucleus in the mouse spinal cord.

    Neuroscience·2015
    Same author

    Aging-dependent changes in the cellular composition of the mouse brain and spinal cord.

    Neuroscience·2015

    Hypothalamic epinephrine originates centrally, not from the adrenal glands. Surgical transection of ascending projections significantly depleted epinephrine in the hypothalamus.

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Neurochemistry

    Background:

    • Epinephrine is a key neurotransmitter and hormone.
    • Its precise origin within the hypothalamus has been debated.
    • Understanding epinephrine's source is crucial for neurological research.

    Purpose of the Study:

    • To investigate the origin of epinephrine within the hypothalamus.
    • To differentiate between adrenal and central sources of hypothalamic epinephrine.

    Main Methods:

    • Adrenal demedullation was performed in subjects.
    • Surgical hemisection of ascending hypothalamic projections was conducted.
    • Hypothalamic epinephrine concentrations were measured post-intervention.

    Main Results:

    Related Experiment Videos

    • Adrenal demedullation did not alter hypothalamic epinephrine levels.
    • Surgical transection of ascending projections led to a ~60% depletion of ipsilateral hypothalamic epinephrine.
    • These findings indicate a central source for hypothalamic epinephrine.

    Conclusions:

    • Hypothalamic epinephrine is primarily of central origin.
    • The adrenal medulla is not the source of hypothalamic epinephrine.
    • Ascending projections are critical for maintaining hypothalamic epinephrine levels.