Toxic epidermal injury following intraarterial adriamycin treatment

Toxic epidermal injury was induced in the right forearm and thumb of a 74-year-old woman following two courses of 28 mg/m2 Adriamycin infused in the brachial artery with a three-week interval. The toxic epidermal injury was treated with a wet dressing solution and a neomycin cream without corticoids; it healed in one month. Afterwards the woman received 22 courses of Adriamycin intravenously or intraarterially in 5.5 or 11 mg/m2 doses, but the toxic epidermal injury did not occur.