[Hepatoma after long-term administration of griseofulvin]

After the 12- and 14-month administration of the preparation gricin to ten white and two bare (nunu) mice in hepatic tissue in addition to diffuse and nodular hyperplasia hepatomas developed. The ultrastructural changes of tumour cells were not typical and involved above all GER, nuclei and nucleoli. They corresponded to findings of experimental carcinogenesis and human hepatomas.