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Dietary saccharin kinetics

W A Colburn, I Bekersky, H P Blumenthal

    Clinical Pharmacology and Therapeutics
    |October 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    This study investigated saccharin pharmacokinetics in humans. Results show rapid absorption and elimination, with saccharin distribution favoring lean body mass, suggesting potential high-retention compartments.

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    Area of Science:

    • Pharmacokinetics
    • Toxicology
    • Human Physiology

    Background:

    • Saccharin is a widely used artificial sweetener.
    • Understanding its metabolic fate is crucial for safety assessment.

    Purpose of the Study:

    • To determine the pharmacokinetic profile of saccharin in adult humans.
    • To assess saccharin absorption, distribution, metabolism, and excretion (ADME) parameters.

    Main Methods:

    • Six adult females received divided doses of saccharin over 3 days.
    • Plasma and urine samples were analyzed for saccharin concentrations.
    • Kinetic parameters including half-life and volume of distribution were calculated.

    Main Results:

    • Saccharin exhibited rapid absorption, with peak plasma levels within 0.5-1.0 hours.

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  • Renal clearance exceeded glomerular filtration rate.
  • Mean elimination half-life was 7.5 hours; mean volume of distribution was 264 L.
  • Saccharin distribution correlated with lean body mass, not total body mass.

    • Conclusions:

    • Saccharin is rapidly absorbed and eliminated, but its distribution suggests it does not readily enter adipose tissue.
    • Findings indicate potential for high-retention compartments, warranting further investigation into long-term saccharin accumulation.