Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Androgens and the thymus

P Pearce, B A Khalid, J W Funder

    Endocrinology
    |October 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    The thymus contains androgen receptors that bind dihydrotestosterone (DHT). Androgen receptor levels vary by sex and age, and are influenced by castration and DHT administration.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Primary Aldosteronism: New Answers, New Questions.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2015
    Same author

    The supplementation of levothyroxine among indigenous people in endemic goitre areas: The impact of therapy.

    Asia Pacific journal of clinical nutrition·2014
    Same author

    Effects of consumption of edible oils for a period of 4 months on the ultrastructure of the aorta of spontaneously hypertensive rats.

    Asia Pacific journal of clinical nutrition·2014
    Same author

    Vitamin E levels in soleus muscles of experimentally induced hyperthyroid rats differ consequent to feeding of edible oils.

    Asia Pacific journal of clinical nutrition·2014
    Same author

    Acute effects of acarbose on post-prandial glucose and triglycerides in type 2 diabetics following intake of different Malaysian foods.

    Asia Pacific journal of clinical nutrition·2014
    Same author

    Serum lipids of castrated rats given hormonal replacement and fed diets with added soybean oil or palm oil.

    Asia Pacific journal of clinical nutrition·2014
    Same journal

    Long Non-Coding RNAs Mediate Endocrine Signaling and Resistance in Prostate Cancer.

    Endocrinology·2026
    Same journal

    Repeated Chemogenetic Activation of C1 Catecholamine Neurons Reduces Subsequent Glucoprivic Responses and Mimics HAAF.

    Endocrinology·2026
    Same journal

    Postnatal exposure to maternal hypothyroidism leads to developmental delay and metabolic dysregulations in male mice.

    Endocrinology·2026
    Same journal

    Discovery proteomics identification of factors contributing to gonadotropin β expression.

    Endocrinology·2026
    Same journal

    3D genome architecture and epigenetic regulation of lineage identity in advanced prostate cancer.

    Endocrinology·2026
    Same journal

    Prefrontal-medullary circuitry is necessary for sex-specific responses to metabolic stress in rats.

    Endocrinology·2026
    See all related articles

    Area of Science:

    • Endocrinology
    • Immunology
    • Molecular Biology

    Background:

    • The thymus is a primary lymphoid organ crucial for T-cell maturation.
    • Androgen receptors (AR) are nuclear receptors that mediate the effects of androgens.
    • The role of androgens and their receptors in thymic function is not fully understood.

    Purpose of the Study:

    • To characterize androgen receptors in rat and mouse thymus.
    • To investigate the regulation of thymic androgen receptors by androgens and glucocorticoids.

    Main Methods:

    • Radioligand binding assays using tritiated dihydrotestosterone ([3H]DHT).
    • Analysis of androgen receptor concentration in response to castration, DHT administration, and dexamethasone treatment.
    • Assessment of thymic weight and cellularity.

    Related Experiment Videos

    Main Results:

    • High-affinity, limited-capacity binding sites for [3H]DHT were identified in thymic cytoplasm, consistent with androgen receptors.
    • Thymic androgen receptor concentration was higher in males than females and increased with age.
    • Castration led to thymic hypertrophy and decreased AR levels per organ weight.
    • DHT administration in castrated mice prevented thymic hypertrophy and increased AR levels.
    • Dexamethasone induced thymolysis, with a relative increase in AR concentration in resistant thymocytes.

    Conclusions:

    • The thymus expresses functional androgen receptors with characteristics similar to those in classical target tissues.
    • Androgen receptor levels in the thymus are modulated by sex hormones, age, and glucocorticoids.
    • Androgen receptors are primarily located in the glucocorticoid-resistant thymocyte subpopulation.