[Cerebral catecholamines in acute rat poisoning with dimethoxydichlorovinyl phosphate]

Fluorescent histochemistry was used in experiments on rats to demonstrate that 30 minutes after administration of the anticholinesterase insecticide dimethoxydichlorvinyl phosphate (DDVPh) in a dose of 10 mg/kg there were changes in the catecholamine content in the brain structures. These changes involved the increased dopamine content in the caudate, adjacent and septal nuclei, as well as the increased noradrenaline content in the blue spot. On premedication with atropine (5 mg/kg) 20 minutes before DDVPh, the content of dopamine in the caudate and adjacent nuclei and of noradrenaline in the blue spot remained within normal. However, in the presence of these phenomena, the depot of catecholamines was depleted in the black substance, A-10 area and in the inferior nucleus of the terminal fibers.