[Effect of ethyl alcohol, nicotine, and both combined on certain parameters of chick embryo development]

Experiments on 220 chick embryos were made to study the embryotoxic action of ethyl alcohol and nicotine administered alone and combined, depending on the drug dose, route and frequency of administration. It has been disclosed that the toxic effect of the drugs manifests primarily at the cellular and subcellular levels and mainly affects the cardiovascular system and liver. The drug side effects increased on repeated administration. Combined use of alcohol and nicotine does not lead to potentiation of their toxic effect on the developing embryo.