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[Acquired generalized anemic nevus]

A Dupré, J L Bonafe, H Jouas

    Dermatologica
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Generalized nevus anemicus in an adult showed permanent vasoconstriction and high catecholamine levels in affected skin areas. The exact cause of this rare condition remains unknown despite investigations.

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    Area of Science:

    • Dermatology
    • Pathophysiology
    • Pharmacology

    Background:

    • Nevus anemicus is a congenital skin condition characterized by hypopigmented macules.
    • Generalized presentations are rare, and etiological factors are not well understood.
    • Previous associations with phacomatosis and pheochromocytoma have been noted but are not universal.

    Observation:

    • A case of generalized nevus anemicus in an adult is presented.
    • Pharmacological testing revealed persistent vasoconstriction in the hypopigmented (anemic) skin areas.
    • Significantly elevated cutaneous catecholamine levels (sevenfold increase) were measured in the affected areas compared to normal skin.

    Findings:

    • The study investigated a potential increase in amine precursor uptake and decarboxylation (APUD) cells as a cause for local catecholamine hypersecretion.

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  • Histochemical staining (Grimelius' stain) for APUD cells yielded negative results.
  • No definitive etiological mechanism for the observed vasoconstriction and catecholamine levels was identified.

    • Implications:

    • This case highlights the persistent vasoconstriction and elevated catecholamines in generalized nevus anemicus.
    • The findings suggest a localized vascular regulatory abnormality.
    • Further research is needed to elucidate the underlying pathophysiology of this rare dermatological condition.