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Prolactin secretion in Cushing's disease

A Caufriez, D Désir, M Szyper

    The Journal of Clinical Endocrinology and Metabolism
    |October 1, 1981
    PubMed
    Summary

    Prolactin (PRL) secretion is altered in Cushing's disease, with elevated levels and disrupted daily rhythms. Successful pituitary surgery normalized prolactin secretion in patients, highlighting the link between Cushing's disease and hormonal balance.

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    Area of Science:

    • Endocrinology
    • Neuroendocrinology
    • Hormone Research

    Background:

    • Cushing's disease is characterized by excess cortisol production.
    • Alterations in other pituitary hormones, like prolactin (PRL), are not fully understood in this condition.
    • Understanding PRL secretion patterns is crucial for comprehensive patient management.

    Purpose of the Study:

    • To investigate prolactin secretion patterns in patients with Cushing's disease.
    • To assess the impact of Cushing's disease on basal and stimulated PRL levels.
    • To evaluate the effect of successful treatment on PRL secretion.

    Main Methods:

    • Evaluated prolactin (PRL) secretion in 11 patients diagnosed with Cushing's disease.
    • Measured basal morning PRL levels and PRL reactivity to TRH and hypoglycemia.
    • Assessed 24-hour mean PRL levels and nyctohemeral rhythm.
    • Monitored PRL secretion post-selective pituitary adenomectomy.

    Main Results:

    • Patients with Cushing's disease exhibited elevated basal morning PRL levels compared to healthy individuals.
    • Most patients showed normal PRL reactivity to TRH and hypoglycemia.
    • Elevated 24-hour mean PRL levels were observed, with altered daily secretion rhythms.
    • Successful surgical cure of Cushing's disease normalized PRL secretion.

    Conclusions:

    • Cushing's disease is associated with significant alterations in prolactin secretion, including elevated levels and disrupted circadian patterns.
    • These prolactin abnormalities are reversible upon successful treatment of the underlying pituitary adenoma.
    • Pituitary surgery for Cushing's disease effectively restores normal prolactin secretory dynamics.

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