Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pattern-onset visual evoked potentials in suspected multiple sclerosis

M J Aminoff, A L Ochs

    Journal of Neurology, Neurosurgery, and Psychiatry
    |July 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Changes in the thalamus in atypical parkinsonism detected using shape analysis and diffusion tensor imaging.

    AJNR. American journal of neuroradiology·2013
    Same author

    Fall frequency and risk assessment in early Parkinson's disease.

    Parkinsonism & related disorders·2012
    Same author

    Trends in American Board of Psychiatry and Neurology specialties and neurologic subspecialties.

    Neurology·2010
    Same author

    Safety and tolerability of putaminal AADC gene therapy for Parkinson disease.

    Neurology·2009
    Same author

    Invited article: The ABPN maintenance of certification program for neurologists: past, present, and future.

    Neurology·2008
    Same author

    Recommendations for the clinical use of somatosensory-evoked potentials.

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2008
    Same journal

    Global epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Diagnostic accuracy of a two-cut-off approach using the FAQ/MMSE ratio and FAQ for clinical preselection of patients for anti-amyloid therapy.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Cancer risk and mortality in patients with multiple sclerosis in Finland: a retrospective population-based cohort study.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Visuospatial working memory in Huntington's disease: behavioural and structural brain correlates.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Characteristics and outcomes in electric scooter-related traumatic brain injuries in Helsinki.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Chronological ageing and ovarian reserve in MS: insights from anti-Müllerian hormone and disability progression.

    Journal of neurology, neurosurgery, and psychiatry·2026
    See all related articles

    Pattern-onset visual evoked potentials (VEPs) offer superior diagnostic accuracy for multiple sclerosis compared to pattern-reversal VEPs. This method enhances detection of abnormalities, improving diagnostic yield in suspected cases.

    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Neurology

    Background:

    • Visual evoked potentials (VEPs) are crucial for assessing visual pathway function.
    • Multiple sclerosis (MS) can affect the visual system, necessitating reliable diagnostic tools.

    Purpose of the Study:

    • To compare the diagnostic efficacy of pattern-onset VEPs versus pattern-reversal VEPs in patients with suspected multiple sclerosis.
    • To evaluate the sensitivity and specificity of each VEP technique in detecting visual pathway abnormalities.

    Main Methods:

    • Monocular stimulation using checkerboard pattern-reversal and pattern-onset techniques.
    • VEPs were recorded in 11 normal subjects and 105 patients with suspected MS.
    • Analysis focused on VEP latency and waveform characteristics.

    Related Experiment Videos

    Main Results:

    • Pattern-onset VEPs were generally larger, better defined, and less ambiguous than pattern-reversal VEPs in normal subjects.
    • In patients with suspected MS, pattern-onset VEPs detected abnormalities in 96% of affected eyes, compared to 59% for pattern-reversal.
    • Increased VEP latency was found in 96% of abnormal cases using pattern-onset, versus 75% with pattern-reversal.

    Conclusions:

    • Pattern-onset VEPs demonstrate higher sensitivity in detecting visual pathway abnormalities in suspected MS.
    • The pattern-onset technique offers a potentially greater diagnostic yield than conventional pattern-reversal VEPs for MS investigation.