Carcinogenic effect of N-nitrosobis(2-hydroxypropyl)-amine in rabbits

The carcinogenic effect of N-nitrosobis(2-hydroxypropyl)amine (BHP) was studied in rabbits. The animals received the compound in drinking water in concentrations of 1000 ppm for 25 weeks and the survivors were sacrificed 60 weeks after the treatment was begun. Whereas no tumors were found in controls, 3 out of 6 treated rabbits developed hapatic lesions (hepatocellular adenoma, hemangioma, and angiosarcoma), and 3 animals developed lung tumors (adenoma and hemangioma); no pancreatic neoplasms were observed.