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Related Experiment Videos

Management of asymptomatic hyperuricemia

W B Duffy, H O Senekjian, T F Knight

    JAMA
    |November 13, 1981
    PubMed
    Summary

    For asymptomatic hyperuricemia, routine hypouricemic therapy is not recommended. Current evidence does not support long-term benefits for gout, kidney stones, or cardiovascular disease risk.

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    Area of Science:

    • Nephrology
    • Rheumatology
    • Cardiovascular Medicine

    Background:

    • Hyperuricemia is associated with increased incidence of gout and renal stones.
    • The link between hyperuricemia and interstitial nephritis (urate nephropathy) is unclear.
    • The association between elevated serum uric acid and cardiovascular disease risk is undefined.

    Purpose of the Study:

    • To evaluate the evidence for long-term benefits of hypouricemic therapy in asymptomatic hyperuricemia.
    • To clarify the relationship between hyperuricemia and renal and cardiovascular diseases.

    Main Methods:

    • Review of recent data and existing evidence regarding hyperuricemia and its complications.
    • Analysis of the relationship between serum uric acid levels and the risk of gout, renal stones, interstitial nephritis, and cardiovascular disease.

    Main Results:

    • No substantial long-term benefits have been demonstrated for long-term hypouricemic therapy.
    • No clear relationship exists between hyperuricemia and the development of interstitial nephritis.
    • The relationship between elevated uric acid and cardiovascular disease risk remains undefined.

    Conclusions:

    • A conservative approach is recommended for patients with asymptomatic hyperuricemia.
    • Routine institution of hypouricemic therapy is not advised for asymptomatic hyperuricemia.

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