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[Clinical studies of cefoxitin in the pediatric field (author's transl)]
Abstract:
1. The in vitro antibacterial activity of cefoxitin was nearly equal to that of CEZ and CET against the 6 species of clinically isolated strains. Cefoxitin, furthermore, had an antibacterial activity against the strains of P. morganii resistant to CEZ and CET. 2. Cefoxitin was applied to a total of 17 patients including 6 cases of bronchitis, 5 of pneumonia, 2 of enteritis, and 1 each of pharyngitis, laryngitis, sinusitis and lymphadenitis. The results showed an efficacy rate of 88%. In the 6 patients from whom the isolation of pathogenic organisms was possible, the bacteriological response to cefoxitin was appreciable the efficacy rate being 83%. Thus, it is considered that cefoxitin also has a significant antibacterial activity in vivo. 3. As to the side effects following the administration of cefoxitin, urticaria-like eruption was observed in 1 case, and an elevation of transaminase in another. These findings, however, became normal soon after discontinuation of cefoxitin treatment.
Insights
Cefoxitin demonstrates potent in vitro and in vivo antibacterial activity, including against resistant strains. This cephalosporin antibiotic showed high efficacy in treating various infections with minimal side effects.
Area of Science:
- Infectious Diseases
- Pharmacology
- Microbiology
Context:
- Antibiotic resistance is a growing global health concern.
- Cephalosporins are a class of beta-lactam antibiotics widely used to treat bacterial infections.
- The emergence of resistance to existing antibiotics necessitates the development and evaluation of new therapeutic agents.
Purpose:
- To evaluate the in vitro and in vivo antibacterial activity of cefoxitin.
- To assess the clinical efficacy and safety of cefoxitin in patients with various bacterial infections.
- To compare the activity of cefoxitin with other cephalosporins against clinically isolated strains, including resistant ones.
Summary:
- Cefoxitin exhibited comparable in vitro antibacterial activity to cefazolin (CEZ) and cefotiam (CET) against six common bacterial species.
- Notably, cefoxitin demonstrated efficacy against Proteus morganii strains resistant to CEZ and CET.
- In a clinical study of 17 patients, cefoxitin achieved an 88% efficacy rate for various infections, with an 83% bacteriological response rate in cases where pathogens were identified.
Impact:
- Cefoxitin shows significant promise as an effective antibiotic for treating a range of bacterial infections, including those caused by resistant organisms.
- The favorable efficacy and safety profile suggest cefoxitin could be a valuable addition to the antibiotic armamentarium.
- Further research may explore cefoxitin's role in combating multidrug-resistant bacterial infections.