[Microcirculation tolerance for physical loading and homeostatic indices in stenocardia]

Area of Science:

• Cardiology
• Microcirculation Research
• Vascular Biology

Background:

• Angina pectoris is associated with significant microcirculatory impairments.
• Conjunctival biomicroscopy reveals widespread vascular lesions in these patients.

Purpose of the Study:

• To investigate the role of microcirculatory lesions in angina pectoris.
• To correlate microcirculatory changes with disease progression and patient outcomes.

Main Methods:

• Utilized conjunctival biomicroscopy to assess microvascular integrity in 80 angina pectoris patients.
• Monitored disease progression, physical strain tolerance, and blood lipid and coagulation parameters.

Main Results:

• Marked extravascular, vascular, and intravascular microcirculatory lesions were observed.
• These lesions progressed with the development of chronic coronary insufficiency.
• Microcirculatory disorders correlated with reduced physical tolerance, elevated cholesterol and triglycerides, and increased blood coagulability.

Conclusions:

• Microcirculatory dysfunction is a key feature of angina pectoris, linked to disease severity and impaired physiological responses.
• In patients without typical ECG ischemic shifts during attacks, microcirculatory disorders play a more significant pathogenetic role.