[Changes in blood biochemical parameters during physical exercise and recovery after prior diazepam administration]

The study involved 51 healthy males aged 20 -- 24, divided into two groups. Group I (30 subjects) performed exercise on a cycle ergometer with the load increasing according to the following schedule: 1 W/kg for six minutes, 2 W/kg -- six minutes, and 3 W/kg -- six minutes. The remaining 21 subjects (group II) performed identical exercise one hour after they had been administered 10 mg of diazepam (Relanium-Polfa). The determinations made included arterial blood levels of FFA, triglyceride, and glucose before the exercise, after each successive phase of the exercise, and in the course of restitution (30 minutes and 4 hours after the exercise). One hour after diazepam administration, the FFA, triglyceride and glucose levels decreased. After the successive phases of the exercise, the FFA levels were significantly lower among group II subjects, and continued to be so also in the 30th minute after the exercise. The decrease in the triglyceride levels during the exercise was higher among the diazepam subjects, and they were slightly lower also in the course of restitution. In both groups the glucose levels gradually increased after each phase of the exercise, and the increase after the third phase was higher among the diazepam subjects. During restitution the glucose concentration was higher than before the exercise, and slightly higher in group II.