Rapid effects of acrylamide on spiroperidol and serotonin binding in neural tissue

The effects of in vivo exposure to acrylamide on 3H-spiroperidol binding to striatal and (3)5-HT binding to forebrain membranes were investigated. Rats were gavaged with 100 mg/kg acrylamide and sacrificed at various times thereafter. Rapid changes were seen with specific binding of spiroperidol increasing by 1/2 hour and 5-HT binding by 2 hours after acrylamide treatment. Although the overall effect of acrylamide was to elevate binding for at least 24 hours, binding of spiroperidol may have exhibited a biphasic profile. The possibility of dual time-dependent mechanisms involved in the effects of acrylamide is discussed.