Radioactive 2-deoxy-D-glucose incorporation into the prefrontal and premotor cortex of the monkey performing a...

Radioactive 2-deoxy-D-glucose (2-DG) incorporation into the monkey prefrontal and premotor cortex was studied in relation to extention-flexion movement at the wrist joint in two experimental and two control monkeys. With 2-DG injection and 45 min' intensive task performance thereafter, the following areas showed increased accumulations of radioactive glucose: the dorsomedial and dorsolateral prefrontal areas, including the lateral and medial banks of the principle sulcus; the ventral prefrontal and orbitofrontal areas; the cingulate gyrus, and the premotor cortex. In these areas, patch- or strip-like patterns were observed in the accumulation of 2-DG.