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[Hairy cell leukaemia with severe bone marrow insufficiency. Complete remission after chemotherapy in two patients
Comple remission was obtained in two patients with hairy cell leukaemia and severe bone marrow insufficiency, using combined chemotherapy (rubidazone, arabinosyl cytosine, 6-mercaptopurine and cyclophosphamide). The remissions -- as demonstrated by normal blood cell counts and differentials and complete disappearance of hairy cells and fibrosis in bone marrow biopsies -- have now persisted for 6 and 3 months respectively. Intensive chemotherapy should be considered in patients who, after splenectomy, still have severe bone marrow depletion with persistent anaemia, neutropenia and/or life-threatening thrombocytopenia. Protected environment in a haematology intensive care unit is a prerequisite of intensive chemotherapy in such patients.
Comple remission was obtained in two patients with hairy cell leukaemia and severe bone marrow insufficiency, using combined chemotherapy (rubidazone, arabinosyl cytosine, 6-mercaptopurine and cyclophosphamide). The remissions -- as demonstrated by normal blood cell counts and differentials and complete disappearance of hairy cells and fibrosis in bone marrow biopsies -- have now persisted for 6 and 3 months respectively. Intensive chemotherapy should be considered in patients who, after splenectomy, still have severe bone marrow depletion with persistent anaemia, neutropenia and/or life-threatening thrombocytopenia. Protected environment in a haematology intensive care unit is a prerequisite of intensive chemotherapy in such patients.