Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toxic megacolon in ulcerative colitis: a continuing challenge

T J Muscroft, P M Warren, P Asquith

    Postgraduate Medical Journal
    |April 1, 1981
    PubMed
    Summary

    Toxic megacolon (TM) incidence in severe ulcerative colitis (UC) remained unchanged despite medical advances. Earlier surgery is crucial for prevention, though it may lead to some unnecessary colectomies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Fractal Electronics for Stimulating and Sensing Neural Networks: Enhanced Electrical, Optical, and Cell Interaction Properties.

    Advances in neurobiology·2024
    Same author

    How neurons exploit fractal geometry to optimize their network connectivity.

    Scientific reports·2021
    Same author

    Fractal Electrodes as a Generic Interface for Stimulating Neurons.

    Scientific reports·2017
    Same author

    Seeing shapes in seemingly random spatial patterns: Fractal analysis of Rorschach inkblots.

    PloS one·2017
    Same author

    Impact of small-angle scattering on ballistic transport in quantum dots.

    Physical review letters·2012
    Same author

    Ventilatory responses after major surgery and high dependency care.

    British journal of anaesthesia·2012

    Area of Science:

    • Gastroenterology
    • Colorectal Surgery
    • Internal Medicine

    Background:

    • Toxic megacolon (TM) is a severe complication of ulcerative colitis (UC).
    • Understanding TM's incidence, predisposing factors, management, and outcomes is critical for patient care.
    • Reviewing historical data helps assess changes in treatment efficacy over time.

    Purpose of the Study:

    • To review and compare the incidence, predisposing factors, management, and outcomes of toxic megacolon (TM) in severe ulcerative colitis (UC).
    • To evaluate changes in TM occurrence and mortality before and after January 1973.
    • To assess the impact of evolving surgical and medical management strategies on TM outcomes.

    Main Methods:

    • A retrospective review of 65 cases of severe ulcerative colitis (UC) with toxic megacolon (TM).

    Related Experiment Videos

  • Comparison of data from two successive 6-year periods, before and after January 1973.
  • Analysis of predisposing factors, management approaches, and patient outcomes, including mortality.

    • Main Results:

    • Nineteen episodes of TM occurred in 18 patients; the incidence remained unchanged despite efforts towards earlier surgery and intensive medical therapy.
    • Emergency operative mortality for UC decreased from 36% to 21%, but TM mortality remained high at 30%.
    • Colonic perforation was the primary cause of death, with mortality linked to increased age, longer pre-operative hospital stay, and low serum albumin levels.

    Conclusions:

    • The incidence of toxic megacolon (TM) in severe ulcerative colitis (UC) did not decrease despite advances in medical therapy and a trend towards earlier surgical intervention.
    • Mortality from TM remains significant, primarily due to colonic perforation, and is associated with specific patient factors.
    • Earlier surgical intervention is emphasized for TM prevention, acknowledging the potential for increased, albeit potentially unnecessary, emergency colectomies.