[Parathyroid hormone and calcitonin in acromegaly]

The functional state of parathyroid glands and calcitonin-produced thyroid C-cells was studied in 25 patients with acromegaly. 14 subjects were in the active stage of the disease and 11 persons developed clinical remission. The study on parathyroid hormone (PTH) and calcitonin (CT) basal levels was performed by radioimmunoassay, using the standard test-sets of DRG K degrees (USA). It was shown that acromegaly is characterized by the secondary hyperparathyrosis occurrence, accompanied by a typical disorder of functional interactions between parathyroid hormone and calcitonin. During the stabilized stage of the disease PTH and CT basal levels decrease, not reaching, however, normal values. Besides, the active form of hypercalcitoninemia manifestation, depending on the disease duration, was found out.