[Comparative study of dysproteinemia and proteinuria in diabetic nephroangiopathies]

Albumin clearance and proteinuria selectivity were studied in 61 patients with diabetes mellitus of different severity by means of disc-electrophoresis. It was shown that the total protein excretion and albumin clearance are not dependent on the disease severity, but they are more intensive in patients with pronounced nephropatic symptoms. 3 degrees of proteinuria selectivity were detected in the patients examined: high, moderate and low (39.3, 44.3 and 16.4% of the patients, respectively). The extent of proteinuria selectivity was not dependent on diabetes severity and decreased in the process of the renal affection development, showing the change in the glomerular basal membrane permeability. The studies of proteinuria selectivity may serve as an additional criterion for early glomerulosclerosis diagnosis and therapy in diabetes mellitus.