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Abstract:
The thymus dysfunction induced by different doses of lymphocyte-stimulating substance, thymozine, antilymphocyte immunoglobulin and prednisolone effect upon the hormonal-immunologic balance of the hypophyseal-thymus-adrenocortical system, was studied in guinea pigs. It was stated that thymomegalia is accompanied by intensified lymphopoiesis (mainly, owing to T-lymphocytes), somatostimulating hormone and prolactin hypersecretion by adenohypophysis and the adrenocortical glucocorticoid function inhibition. Inverse proportional changes are seen in the thymus hypoplasia. The data obtained may serve as a reliable criterion for physiology and pathology of the thymus and conjugated organs and systems.