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Subunit assembly of hemoglobins A and S
Progress in Clinical and Biological Research
|January 1, 1981
Abstract:
It has been demonstrated that a difference in affinities of beta A and beta S chains for alpha chains exists. Furthermore, differential rates of dissociation of beta A and beta S chain tetramers have also been measured. It appears that the overall assembly of Hb A and Hb S, in vitro, can be governed by either the dissociation or combination reactions of its non-alpha-subunit.