Transfer of pentylenetetrazol sensitization to amygdaloid kindling

Rats repeatedly injected with initially subconvulsive doses of pentylenetetrazol (PTZ) eventually became sensitized to the drug (displayed twitching and myoclonic jerks). Other rats injected with increased doses of PTZ displayed both sensitization and generalized convulsions. Both groups subsequently developed generalized amygdaloid kindled seizures significantly faster than control rats, but did not differ significantly from each other in their rate of kindling. These results indicate that substantial transfer facilitation of electrical kindling occurs whether sensitization alone, or sensitization together with convulsions are induced by injection of PTZ.