Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pentobarbital induces a naloxone-reversible decrease in mesolimbic self-stimulation threshold

T F Seeger, K R Carlson, J M Nazzaro

    Pharmacology, Biochemistry, and Behavior
    |October 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pallidotomy: a comparison of responders and nonresponders.

    Neurosurgery·2002
    Same author

    Correct utilization and management of peripherally inserted central catheters and midline catheters in the alternate care setting.

    Journal of intravenous nursing : the official publication of the Intravenous Nurses Society·2000
    Same author

    Successful treatment of postoperative meningitis due to Haemophilus influenzae without removal of an expanded polytetrafluoroethylene dural graft.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1998
    Same author

    Ethanol and cocaine intake by rats selectively bred for oral opioid acceptance.

    Pharmacology, biochemistry, and behavior·1997
    Same author

    Selective breeding for oral opioid acceptance or rejection in rats.

    Pharmacology, biochemistry, and behavior·1996
    Same author

    3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.

    Journal of medicinal chemistry·1996

    Sodium pentobarbital at intermediate doses significantly lowered brain reward thresholds in rats, an effect reversed by naloxone. This suggests a role for opioid systems in pentobarbital

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Intracranial self-stimulation (ICSS) is a model for studying reward and motivation.
    • The ventral tegmental area is a key component of the brain's reward circuitry.
    • Pentobarbital and naloxone are known psychoactive drugs with effects on neurotransmitter systems.

    Purpose of the Study:

    • To investigate the effects of sodium pentobarbital and naloxone on ICSS in rats.
    • To determine the dose-dependent effects of pentobarbital on reward thresholds.
    • To explore the interaction between pentobarbital and naloxone in modulating ICSS.

    Main Methods:

    • Rats were implanted with electrodes in the ventral tegmental area.
    • ICSS thresholds were measured using a rate-independent current titration paradigm.

    Related Experiment Videos

  • Different doses of sodium pentobarbital and naloxone were administered.

    • Main Results:

    • A low dose of pentobarbital (5 mg/kg) had no significant effect on ICSS thresholds.
    • An intermediate dose of pentobarbital (10 mg/kg) significantly lowered ICSS thresholds by 17%.
    • A high dose of pentobarbital (20 mg/kg) caused ataxia, preventing reliable responding.
    • Naloxone (2 mg/kg) reversed the threshold-lowering effect of pentobarbital.
    • Naloxone alone did not affect ICSS thresholds.

    Conclusions:

    • Intermediate doses of sodium pentobarbital enhance brain reward function.
    • The effects of pentobarbital on ICSS appear to be mediated, in part, by opioid systems.
    • Naloxone can antagonize the reward-enhancing effects of pentobarbital.