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Circulating immune complexes in patients with lung cancer
Thorax
|January 1, 1981
Summary
Immune complexes, measured by Clq binding activity, were elevated in 34% of lung cancer patients. This marker showed potential for monitoring disease progression in cancer patients.
Area of Science:
- Oncology
- Immunology
Background:
- Immune complexes are implicated in various diseases, including cancer.
- Assessing immune complex levels may offer insights into disease status.
Purpose of the Study:
- To investigate the presence and significance of immune complexes in lung cancer patients.
- To evaluate the correlation of immune complex levels with clinical parameters.
Main Methods:
- Sera from 41 lung cancer patients and 41 non-malignant controls were analyzed.
- The 125Iodine Clq binding test was employed to detect immune complexes.
Main Results:
- Increased Clq binding activity was observed in 34% of lung cancer patients versus 24% of controls.
- Elevated Clq binding activity correlated with the extent of lung cancer, not histological type or survival.
- No association was found with white cell count or ESR.
Conclusions:
- Clq binding activity may serve as a biomarker for monitoring lung cancer progression.
- This assay could potentially aid in assessing treatment response in lung cancer.