Lack of induction of dominant lethal mutations in male mice by nalidixic acid

Nalidixic acid (NA) in single or in 5 consecutive daily doses of 100 or 1000 mg/kg produced no dominant lethal mutational effects in male ddY strain mice during an 8-week mating schedule. Ethylmethanesulfonate (EMS), used as a positive control, produced dominant lethal mutations in the first and second weeks.