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Anti-Tm defines an antigen in the MN blood group system, and 382 Tm + samples were found in tests on 900 random Caucasian, and 500 random Negro bloods. Of the 382 Tm + samples, 373 were also N +, but a further 625 N+ samples were nonreactive with anti-Tm. We have now shown that when the original anti-Tm serum is adsorbed free of anti-T, and is tested against neuraminidase-treated red blood cells, it has anti-N specificity. Further, while anti-Tm cannot be inhibited by sialoglycoprotein (SGP) preparations from untreated N+ red blood cells, it is inhibited by SGP fractions prepared from N+ red blood cells that have been pretreated with neuraminidase. It seems that anti-Tm is directed against a part of the polypeptide backbone of the N SGP.
Anti-Tm defines an antigen in the MN blood group system, and 382 Tm + samples were found in tests on 900 random Caucasian, and 500 random Negro bloods. Of the 382 Tm + samples, 373 were also N +, but a further 625 N+ samples were nonreactive with anti-Tm. We have now shown that when the original anti-Tm serum is adsorbed free of anti-T, and is tested against neuraminidase-treated red blood cells, it has anti-N specificity. Further, while anti-Tm cannot be inhibited by sialoglycoprotein (SGP) preparations from untreated N+ red blood cells, it is inhibited by SGP fractions prepared from N+ red blood cells that have been pretreated with neuraminidase. It seems that anti-Tm is directed against a part of the polypeptide backbone of the N SGP.