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Platelet collection and transfusion using the fenwal CS-3000 cell separator

A J Katz, P V Genco, N Blumberg

|September 1, 1981

Summary

The Fenwal CS-3000 Blood Cell Separator effectively collects platelets for transfusion, with low reaction rates and high-quality products. This apheresis technology shows promise for treating thrombocytopenia.

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Area of Science:

Hematology
Biomedical Engineering

Background:

Plateletpheresis is crucial for managing thrombocytopenia.
Efficient and safe blood cell separation technologies are needed.

Purpose of the Study:

To evaluate the performance of a prototype Fenwal CS-3000 Blood Cell Separator for plateletpheresis.
To assess the quality and safety of collected platelet products.

Main Methods:

Studied a prototype Fenwal CS-3000 Blood Cell Separator in 63 donors and 5 patient transfusions.
Collected data on platelet yield, efficiency, and product contamination.
Monitored donor reactions and patient outcomes post-transfusion.

Main Results:

Collected 4.0 +/- 0.72 x 10(11) platelets per two-hour collection with 45 +/- 6.9% efficiency.

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Product showed minimal leukocyte and red blood cell contamination.

Low incidence (9 of 63) of mild citrate-related donor reactions.

Transfused patients experienced significant platelet count increments and reduced bleeding times.

Conclusions:

The Fenwal CS-3000 prototype is effective for plateletpheresis.
The apheresis system yields high-quality platelet products with good preservation.
This technology offers a safe and efficient option for platelet transfusion therapy.