[The functional sensitivity of the parietal cells in various gastric diseases (author's transl)]

The phenomenon of the spontaneous parietal cell sensitivity not induced by drugs is described in a number of gastric diseases. Different parietal cell sensitivity can be assumed. 1. when there is a shift in the dose response curve between the aid output and continuous intravenous application of a stimulant, 2. when there is a deviation from the linear correlation between the parietal cell mass or rather the parietal cell density, and the maximal acid output, 3. when there is a changed time course of the acid secretion in response to continuous intravenous infusion of a fixed dose of stimulant. A parietal cell hypersensitivity exists in some patients with an uncomplicated duodenal ulcer. A hyposensitivity can be detected in patients with selective vagotomy, isolated chronic atrophic gastritis of the antrum, antrectomy, and chronic atrophic gastritis of fundic mucosa. It is not yet possible to estimate the importance of the different parietal cell sensitivity for the pathophysiology of human gastric diseases.