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Positive family history as a risk factor of obliterative atherosclerosis

V Puchmayer, M Bulvas

    Cor Et Vasa
    |January 1, 1978
    PubMed

    Insights

    A positive family history of peripheral artery disease (PAD) accelerates its development, particularly when combined with other risk factors. However, family history alone or with obesity does not significantly impact PAD progression.

    Area of Science:

    • Vascular Medicine
    • Genetics
    • Epidemiology

    Background:

    • Peripheral artery disease (PAD) is a significant vascular condition.
    • Family history is a known risk factor for cardiovascular diseases.
    • The specific role of family history in PAD progression requires further elucidation.

    Purpose of the Study:

    • To investigate the influence of family history on the development of peripheral artery disease.
    • To determine the significance of a positive family history in conjunction with other risk factors for PAD.

    Main Methods:

    • Clinical, angiological, and biochemical examinations of patients with and without PAD.
    • Detailed family history recording, including myocardial infarction, cerebral accidents, hypertension, diabetes, and peripheral artery occlusive disease (PAOD) in relatives.
    • Statistical analysis of family history in combination with other risk factors.

    Main Results:

    • A positive family history, defined by conditions like PAOD or early-onset cardiovascular events in relatives, is associated with accelerated PAD.
    • Family history plays a significant role only when combined with two or more additional risk factors, notably tobacco smoking.
    • Family history in combination with obesity did not show a significant impact on PAD.

    Conclusions:

    • Positive family history is a contributing factor to PAD development and progression.
    • The interplay between genetic predisposition and lifestyle factors like smoking is crucial in PAD.
    • Obesity does not appear to modify the impact of family history on PAD.

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