Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Theophylline therapy in bronchiolitis. A retrospective study

L J Brooks, G J Cropp

    American Journal of Diseases of Children (1960)
    |October 1, 1981
    PubMed
    Summary

    Theophylline and steroid treatments did not improve outcomes for infants hospitalized with acute bronchiolitis or wheezing. This study suggests these therapies offer no significant benefit for young children with these respiratory conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An Epidemic of Cerebro-spinal Meningitis.

    Transactions of the ... Annual Meeting of the American Climatological Association. American Climatological Association. Annual Meeting·2011
    Same author

    Follow-up of primary snoring in children.

    The Journal of pediatrics·2001
    Same author

    The effect of epoch length and smoothing on infant sleep and waking state architecture for term infants at 42 to 46 weeks postconceptional age.

    Sleep·2000
    Same author

    Comparison of apnea identified by respiratory inductance plethysmography with that detected by end-tidal CO(2) or thermistor. The CHIME Study Group.

    American journal of respiratory and critical care medicine·2000
    Same author

    Regional differences in prevalence and risks of respiratory diseases in children.

    Pediatric pulmonology. Supplement·1999
    Same author

    Agreement among raters in assessment of physiologic waveforms recorded by a cardiorespiratory monitor for home use. Collaborative Home Infant Monitoring Evaluation (CHIME) Study Group.

    Pediatric research·1998

    Area of Science:

    • Pediatrics
    • Pulmonology
    • Clinical Pharmacology

    Background:

    • Bronchiolitis shares clinical and pathophysiologic similarities with asthma, leading to suggestions for bronchodilator drug use.
    • The effectiveness of bronchodilator therapies in treating bronchiolitis remains unproven in scientific literature.

    Purpose of the Study:

    • To evaluate the effectiveness of theophylline, steroids, and inhaled sympathomimetic drugs in treating acute bronchiolitis or wheezing in infants.
    • To compare treatment outcomes between infants who received these therapies and those who did not.

    Main Methods:

    • A retrospective review of 64 children under 18 months hospitalized for their first episode of bronchiolitis or wheezing.
    • Comparison of outcomes between a group of 31 patients receiving theophylline (with or without steroids/sympathomimetics) and a control group of 34 patients receiving no such therapy.

    Main Results:

    • No significant differences in clinical findings, laboratory assessments, or treatment outcomes were observed between the theophylline-treated and untreated groups.
    • The theophylline-treated group was older (9.4 vs. 4.9 months), but this did not appear to influence the lack of observed benefit.

    Conclusions:

    • Theophylline and steroid therapies demonstrated no beneficial effects on the resolution of acute bronchiolitis or wheezing in the majority of infants and small children studied.
    • Current evidence does not support the routine use of theophylline, steroids, or sympathomimetics for treating acute bronchiolitis or wheezing in infants.

    Related Experiment Videos