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Echovirus type 7 meningitis in young children

W R Jarvis, G Tucker

    American Journal of Diseases of Children (1960)
    |November 1, 1981
    PubMed
    Summary

    An echovirus type 7 outbreak caused aseptic meningitis in young children, with symptoms varying by age. Human placental cells offered faster detection of the virus compared to other cell lines.

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    Area of Science:

    • Pediatrics
    • Virology
    • Infectious Diseases

    Background:

    • Aseptic meningitis is a significant concern in pediatric populations.
    • Echovirus infections can cause various clinical manifestations, particularly in infants.

    Purpose of the Study:

    • To describe the clinical and virological characteristics of an echovirus type 7 epidemic in children.
    • To evaluate different cell lines for the detection of echovirus.

    Main Methods:

    • Clinical data collection from pediatric patients diagnosed with aseptic meningitis.
    • Virological analysis using human placental fibroblast, rhesus monkey kidney cells, Vero cells, and human epidermoid (Hep-2) cells to detect cytopathic effects.

    Main Results:

    • The majority of affected children were under one year of age.
    • Cerebrospinal fluid (CSF) pleocytosis was more pronounced in infants younger than 7 months.
    • Human placental fibroblast demonstrated superior performance in rapid viral detection and recovery rates.

    Conclusions:

    • Echovirus type 7 was identified as the causative agent of the aseptic meningitis outbreak in children.
    • Age is a significant factor influencing symptom presentation and CSF findings.
    • Human placental fibroblast is a highly effective cell line for echovirus diagnosis.

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