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Mania associated with LSD ingestion

C R Lake, A L Stirba, R E Kinneman

    The American Journal of Psychiatry
    |November 1, 1981
    PubMed
    Summary
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    Lysergic acid diethylamide (LSD) ingestion can trigger acute intoxication, potentially leading to a delayed manic episode. Lithium therapy effectively resolved the psychotic manic symptoms in this reported case.

    Area of Science:

    • Psychiatry
    • Neuroscience
    • Pharmacology

    Background:

    • Psychoactive substances, including lysergic acid diethylamide (LSD), are known for their profound effects on the central nervous system.
    • Understanding the potential for delayed psychiatric sequelae following hallucinogen use is crucial for clinical practice.

    Observation:

    • A patient presented with acute symptoms consistent with lysergic acid diethylamide (LSD) intoxication after ingestion.
    • Following the resolution of acute intoxication, the patient developed a severe manic episode with psychotic features approximately three weeks later.

    Findings:

    • The manic episode exhibited typical characteristics of a psychotic manic state.
    • The patient's manic symptoms showed a significant positive response to lithium therapy.

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    Implications:

    • This case highlights a potential delayed neurobiological effect of lysergic acid diethylamide (LSD) or its analogues, manifesting as mania.
    • The findings suggest the importance of monitoring for delayed psychiatric symptoms after exposure to certain hallucinogens.
    • Successful treatment with lithium indicates its potential role in managing such drug-induced mood disturbances.