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[Sensitivity in vitro of 192 Proteus strains to several aminoglycosides]
Annali Sclavo; Rivista Di Microbiologia E Di Immunologia
|January 1, 1981
Abstract:
The antibacterial activity of tobramycin, gentamicin, amikacin, sisomicin and kanamycin against 192 strains of genus Proteus has been studied in vitro. Tobramycin and amikacin showed the highest activity. furthermore curves of distribution of frequency, concerning the sensitivity of Proteus mirabilis strains, have been drawn for every tested antibiotic, to study the modal values.
Insights
Tobramycin and amikacin demonstrated the strongest antibacterial activity against Proteus strains in vitro. This study analyzed antibiotic sensitivity distributions for Proteus mirabilis to identify key efficacy values.
Area of Science:
- Microbiology
- Pharmacology
Context:
- Genus Proteus is a significant opportunistic pathogen.
- Antibiotic resistance in Proteus species necessitates ongoing surveillance.
Purpose:
- To evaluate the in vitro antibacterial efficacy of five aminoglycoside antibiotics against 192 strains of the genus Proteus.
- To determine the most effective antibiotics for treating Proteus infections.
Summary:
- Tobramycin and amikacin exhibited the highest antibacterial activity against the tested Proteus strains.
- Frequency distribution curves were generated for Proteus mirabilis sensitivity to each antibiotic.
- Modal values of sensitivity were analyzed to understand population-level responses.
Impact:
- Identifies tobramycin and amikacin as leading therapeutic options for Proteus infections.
- Provides data for guiding antibiotic selection and managing potential resistance.
- Contributes to understanding aminoglycoside effectiveness in clinical microbiology settings.