Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Middle molecule accumulation in uremia: an "extra uremic factor"

R Oulès, C Emond, G Claret

    Artificial Organs
    |January 1, 1981
    PubMed
    Summary

    Middle molecule (MM) levels in uremic patients are not solely due to kidney function decline. Complications and radio-contrast media significantly impact MM accumulation, suggesting varied generation rates.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pharmacokinetic characterisation of a valproate Autism Spectrum Disorder rat model in a context of co-exposure to α-Hexabromocyclododecane.

    Environmental toxicology and pharmacology·2023
    Same author

    Experiences of parents and caregivers in pediatric intensive care units: A qualitative study.

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2022
    Same author

    [Copper-containing intrauterine device (cIUD): Comparison of tolerance and efficacy in nulliparous and parous women over 6 months].

    Gynecologie, obstetrique, fertilite & senologie·2021
    Same author

    Clinical profiles of placenta accreta spectrum: the PACCRETA population-based study.

    BJOG : an international journal of obstetrics and gynaecology·2021
    Same author

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2020
    Same author

    Description of 101 cases of nipple cracks and risk factors via case-control study in eight units of a perinatal network.

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2019

    Area of Science:

    • Nephrology
    • Biochemistry
    • Clinical Chemistry

    Background:

    • Middle molecules (MMs) are retained in uremic patients due to impaired renal function.
    • Understanding MM accumulation is crucial for assessing patient well-being and disease progression.

    Purpose of the Study:

    • To investigate the relationship between plasma MM levels and patient well-being in uremic individuals.
    • To explore factors influencing MM accumulation beyond reduced renal function.

    Main Methods:

    • Plasma MM levels were analyzed in 115 uremic patients using a two-step chromatographic technique.
    • Correlations between MM fractions, small molecule accumulation, residual renal function, hematocrit, and serum parathyroid hormone (PTH) were assessed.

    Main Results:

    Related Experiment Videos

    • Most patients showed low levels of specific MM subpeaks (7a-7d).
    • Higher MM concentrations were observed in patients with complications like infection or hyperparathyroidism.
    • Peak 7d was prominent after radio-contrast media administration.
    • No correlation was found between MM and urea, creatinine, uric acid, residual renal function, or hematocrit.
    • An unexpected correlation was identified between certain MM fractions and serum PTH levels.

    Conclusions:

    • MM accumulation in uremic patients is influenced by factors beyond impaired renal function.
    • Complications and external factors like radio-contrast media administration significantly affect MM levels.
    • The findings suggest variations in MM generation rates possibly linked to PTH breakdown products or other unidentified factors.