Remodeling of the cryosurgical adhesion

A cryosurgical adhesion was considered mature and complete at two weeks. A reexamination of the lesion showed that the adhesion, at two weeks, was mediated by depolarized cells and was not stable. In subsequent months, the cells repolarized, and a remodeling of the adhesion took place. The desmosomal connections between the blunt surfaces of pigment epithelium and Müller's cells were displaced by villous processes that developed from the apical surfaces of repolarizing pigment epithelium. The villi interdigitated with short processes that were elaborated by Müller's cells from a redifferentiated outer limiting membrane.