Characterization of the (rnunz) nude rat. Morphological characteristics of the lymphoid system

A nude mutant (rnunz) arose spontaneously in a colony of Wistar albino rats (the wild-type strain) in Wellington, New Zealand. On gross examination no thymus could be found in the mediastina of young animals, whereas in older mutants lobules of fatty tissue mimicked the appearance of the thymus of the wild-type strain. Lymph nodes from the rnunz strain showed a marked lymphocyte depletion in the thymus-dependent para-cortical region of the node. Peyer's patches from the nude animals also showed a reduced density of small lymphocytes in the interfollicular zones. In the spleen, tissue from the reticular framework surrounding individual arterioles was sometimes completely empty of lymphocytes but the degree of depletion varied. Total leucocyte numbers in the rnunz strain were 28% lower than the wild-type strain. In 10 out of 13 animals T cells were less than 3% of the lymphocytes present (wild-type 35% T cells). The findings are in agreement with studies of the Rowett nude rat (rnu) and the nude mouse.