[Light microscopic and ultrastructural changes in the myocardium in experimental myocardiopathy in rats]

The authors examined the morphological changes in the myocardium of rats with myocardiopathy, caused by electrolytes, steroids and catecholamines. There were fresh and organized microinfarctions, occupying around 17--18% of the volume of the left heart ventricle. Scattered fuxinophilic necrosis were present in the zones outside the infarctions. The electrone microscopic examination of these areas showed vacuolization and crystolisis of mitochondria, dilatation of cysterns of the sarcoplasmic reticulum after dilatation of Z discs of miofibrils and increased folds with herniation of the intercanicular discs. The obtained model belongs to the group of the infarction-like myocardiopathies and resembles the changes in the human myocardium during involvment of the small intramural myocardial arteries and microcirculatory bed.