Related Experiment Video

Updated: Aug 17, 2026

Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
09:23

Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model

Published on: July 29, 2012

Apical aneurysm of Chagas's heart disease

J S Oliveira, J A Mello De Oliveira, U Frederigue

    British Heart Journal
    |October 1, 1981
    PubMed

    Insights

    Chagas

    Area of Science:

    • Cardiology
    • Pathology
    • Parasitology

    Background:

    • Chagas's heart disease is a significant cause of cardiomyopathy.
    • Apical aneurysms are a recognized but incompletely understood complication.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of apical aneurysms in Chagas's heart disease.
    • To explore potential etiological factors and associations of apical aneurysms.

    Main Methods:

    • Retrospective review of necropsy reports.
    • Analysis of cardiac pathology, focusing on apical aneurysms.
    • Correlation with clinical data and mode of death.

    Main Results:

    • Apical aneurysms were more frequent in males, independent of age or heart weight.
    • Presence of apical aneurysm was associated with death from Chagas's cardiomyopathy.
    • Thrombosis within the aneurysm was common; myocardial thinning was also observed.

    Conclusions:

    • Apical aneurysms are linked to Chagas's cardiomyopathy but not the specific mode of death.
    • Ischemia, inflammation, thrombosis, and mechanical factors contribute, but the root cause is parasympathetic nerve cell destruction.

    More Related Videos

    Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates13:55

    Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates

    Published on: January 27, 2019

    In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase08:48

    In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

    Published on: November 5, 2021

    Related Concept Videos

    Mitral Regurgitation I: Introduction01:20

    Mitral Regurgitation I: Introduction

    Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
    Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

    Aortic Regurgitation II: Clinical Features and Diagnostic Tests

    Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
    Endocarditis II: Clinical Features of Infective Endocarditis01:25

    Endocarditis II: Clinical Features of Infective Endocarditis

    Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
    Aneurysm I: Introduction01:30

    Aneurysm I: Introduction

    An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
    American Trypanosomiasis01:22

    American Trypanosomiasis

    Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
    Esophageal Achalasia01:27

    Esophageal Achalasia

    Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...