[Electron cytochemical study of the cerebral adenylate cyclase of rats]

Electron cytochemistry was used to study the distribution of adenylate cyclase in the rat brain cortex and nucleus caudatus. In neurons and glial cells, the enzyme was localized on the outside surface of plasma membrane, within the perinuclear space, in the cisterns of endoplasmic reticulum and the Golgi apparatus. In capillaries, it was detected on the luminal surface of endothelial cells and along the basal layer. The addition of NaF and isoproterenol to the incubation medium led to the increased adenylate cyclase activity.