Clinical evaluation of two fast methods for creatine kinase isoenzyme assay

Sixty patients admitted to the Cardiac Care Unit were evaluated serially for the presence of CK-MB by electrophoresis and by two comparative fast methods each involving a minimal amount of procedural steps. Immunoinhibition was run manually and by centrifugal analysis. Batch ion-exchange was run in an automated fashion. Correlation among the three methods was good. Further, all three methods displayed excellent accuracy with diagnostic efficiencies ranging from 90% (batch ion-exchange) to 95% (electrophoresis). Utilization of the immunoinhibition reagent on a centrifugal analyzer gave high throughput and reliable results.