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Related Experiment Videos

Zinc tolerance tests in chronic uremia

L D Antoniou, R J Shalhoub, S Elliot

    Clinical Nephrology
    |October 1, 1981
    PubMed
    Summary

    Zinc absorption is impaired in hemodialysis patients not taking vitamin D. Vitamin D therapy may improve intestinal zinc absorption in chronic uremia, suggesting a link between vitamin D metabolism and zinc uptake.

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    Area of Science:

    • Nephrology
    • Nutritional Science
    • Gastroenterology

    Background:

    • Chronic uremia affects mineral metabolism.
    • Vitamin D plays a role in nutrient absorption.
    • Zinc deficiency is common in patients with kidney disease.

    Purpose of the Study:

    • To investigate the effect of vitamin D on intestinal zinc absorption in patients undergoing maintenance hemodialysis.
    • To compare zinc absorption between hemodialysis patients with and without vitamin D therapy and healthy controls.

    Main Methods:

    • A zinc tolerance test was performed on 12 control subjects and 20 hemodialysis patients (10 on vitamin D, 10 not).
    • Subjects ingested 50 mg of zinc after baseline plasma zinc measurements.
    • Plasma zinc levels were measured hourly for 4 hours post-ingestion.

    Main Results:

    • Hemodialysis patients not receiving vitamin D showed significantly lower peak plasma zinc levels compared to controls and patients on vitamin D.
    • No significant difference in zinc absorption was observed between controls and patients on vitamin D therapy.
    • Two patients demonstrated normalized zinc tolerance tests when on vitamin D therapy, with abnormal tests when off it.

    Conclusions:

    • Intestinal zinc absorption may be impaired in chronic uremia.
    • Abnormal vitamin D metabolism in uremia likely contributes to impaired zinc absorption.
    • Vitamin D supplementation may be beneficial for improving zinc status in hemodialysis patients.

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