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Growth status of children with and without sickle cell trait

N Rehan

    Clinical Pediatrics
    |November 1, 1981
    PubMed

    Insights

    Children with sickle cell trait (HbAS) are not smaller or lighter than children with normal hemoglobin (HbAA). Anthropometric measurements showed no significant differences when heredity and nutrition effects were excluded.

    Area of Science:

    • Pediatrics
    • Genetics
    • Anthropometry

    Background:

    • Sickle cell trait (HbAS) is common, and previous research suggested it may be associated with reduced growth.
    • Understanding the anthropometric differences in children with sickle cell trait is crucial for public health.

    Purpose of the Study:

    • To investigate whether children with sickle cell trait (HbAS) exhibit different anthropometric measurements compared to children with normal hemoglobin (HbAA).
    • To minimize confounding factors like heredity and nutrition in the comparison.

    Main Methods:

    • Compared anthropometric measurements of 50 children with HbAS to 50 matched children with HbAA.
    • Participants were from polygamous families, with both groups being offspring of the same fathers and living under identical conditions to control for heredity and nutrition.

    Main Results:

    • No significant differences were observed in anthropometric measurements between children with sickle cell trait and those with normal hemoglobin.
    • The study successfully minimized the impact of hereditary and nutritional variables.

    Conclusions:

    • Sickle cell trait (HbAS) alone does not appear to cause significant anthropometric differences in children.
    • Environmental factors like heredity and nutrition play a more significant role in child growth than sickle cell trait.

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