Strong teratocarcinoma transplantation loci, Gt-1 and Gt-2, flank H-2

Evidence is presented for the existence of two strong murine teratocarcinoma transplantation antigens (Gt) on the cell line PCC3. It is shown that the loci governing expression of these antigens are linked to the H-2 complex. These loci have been further mapped with respect to the brachyury marker (T) and H-2: Gt-1 lies 5 +/- 2 crossover units proximal to H-2 and 12 +/- 2 crossover units distal to T; Gt-2 lies 21 +/- 4 crossover units distal to H-2. It is possible that these strong transplantation antigens provide an embryonic analogue to the adult major histocompatibility system.