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Related Experiment Videos

Experimental Campylobacter diarrhea in chickens

G M Ruiz-Palacios, E Escamilla, N Torres

    Infection and Immunity
    |October 1, 1981
    PubMed
    Summary

    A new animal model using 3-day-old chickens effectively simulates Campylobacter jejuni enteritis. This model shows significant diarrhea, weight loss, and mortality, aiding Campylobacter research.

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    Area of Science:

    • Veterinary Medicine
    • Microbiology
    • Animal Models

    Background:

    • Campylobacter fetus subsp. jejuni is a significant cause of bacterial gastroenteritis in humans.
    • Developing reliable animal models is crucial for understanding Campylobacter pathogenesis and developing interventions.

    Purpose of the Study:

    • To establish and characterize an animal model for Campylobacter fetus subsp. jejuni enteritis in young chickens.
    • To evaluate the efficacy of oral inoculation in inducing disease symptoms and identify the minimal infective dose.

    Main Methods:

    • Oral inoculation of 3-day-old chickens with Campylobacter fetus subsp. jejuni.
    • Induction of diarrhea, monitoring weight loss and mortality.
    • Histopathological, immunofluorescence, and electron microscopy analyses of the gastrointestinal tract.

    Main Results:

    • Diarrhea observed in 88% of inoculated chickens with a mean incubation of 45 hours.
    • Minimal infective dose established at 90 bacteria for 90% efficacy; 32% overall mortality.
    • Campylobacter located intracellularly within epithelial cells and phagocytosed by lamina propria mononuclear cells; moderate mononuclear cell infiltration in ileum and cecum without mucosal disruption.

    Conclusions:

    • A 3-day-old chicken model successfully replicates Campylobacter fetus subsp. jejuni enteritis.
    • The model demonstrates key pathological features and bacterial localization, valuable for future research.

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